Identification of High Risk Groups Prone to Spinal Disorders

Identification of High Risk Groups Prone to Spinal Disorders

Introduction

Immobility and paralysis caused by a spinal cord injury (SCI) result in muscle loss and a relative increase in fat. Individuals with SCI are predisposed to medical problems such as lipid abnormalities, glucose intolerance, and an atherogenic tendency for coronary heart disease (CHD). One potential explanation for these secondary medical problems is that they are the consequence of inactivity combined with negative body composition changes that worsen with age.

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The traditional risk factors for CHD as described by the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on the Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults have recently been examined in a group of veterans with SCI (Adult Treatment Panel III). To be able to establish target levels for low-density lipoprotein (LDL) cholesterol, the risk for CHD was calculated. 

Recognizing the existence of these metabolic abnormalities and cardiovascular risk in people with SCI is essential for early diagnosis and a better approach to therapeutic treatment. Appropriate treatments that decrease cardiovascular risk and have the potential to enhance lifespan and quality of life in people with SCI are addressed.

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Conclusion


Adverse changes in body composition, as well as inactivity, predispose people with SCI to metabolic abnormalities, which hasten the development and manifestation of CHD. Muscle atrophy and absolute and/or relative increases in body fat begin soon after injury and continue at an accelerated pace in people with SCI as they become older. Insulin resistance and hyper insulinemia occur in conjunction with problems with carbohydrate and fat metabolism. The pancreas' capacity to adjust for these alterations may deteriorate with damage duration and age.


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